Synthesis, spectral studies, crystal structure and molecular docking of ethyl 6-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]hexanoate

Shetty, Shivaprasad M and Bharath, B R and Latha, Rani N and Sridhar, MA and Loknath, N K and Kumar, Anil N V (2018) Synthesis, spectral studies, crystal structure and molecular docking of ethyl 6-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]hexanoate. Chemical Data Collections, 13. pp. 17-27. ISSN 2405-8300

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Rheumatoid arthritis (RA) is one of the inflammatory joint diseases in a heterogeneous group of disorders that share features of the destruction of the extracellular matrices of articular cartilage and bone. Matrix metalloproteinase (MMP) enzymes (in particular MMP9), are crucial for RA. Given the limited investigation of the MMP9 inhibition by coumarin derivatives, the present study was taken up. A coumarin derivative (ethyl 6-[(4-methyl-2-oxo-2H-chromen-7- yl)oxy]hexanoate) was synthesized, characterized by spectral analysis (1HNMR, 13CNMR, IR, and MS), single crystal XRD and molecular docking was carried out. The title compound C18H22O5 crystallizes in the monoclinic crystal system in P21/c space group. The glide docking score for the title compound is -6.8, compared with -6.6 for co-crystal compound (LT4). The synthesis, characterization and crystal data are discussed.

Item Type: Article
Uncontrolled Keywords: 7-hydroxy-4-methyl coumarin, crystal structure, MMP9, molecular docking, antirheumatoid arthritis
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 15 Jan 2019 09:05
Last Modified: 15 Jan 2019 09:05

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