Predictors of mortality in adult patients with dengue: a study from south India

Acharya, Vasudeva and Khan, Mohammed Fahad and Kosuru, Srinivas and Mallya, Sneha D (2018) Predictors of mortality in adult patients with dengue: a study from south India. International Journal of Research in Medical Sciences, 6 (5). pp. 1605-1610. ISSN 2320-6071

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Abstract

Background: Dengue is one of the important causes of acute febrile illnesses in India. Dengue can be a fatal disease, however there are no reliable markers which can predict mortality among these patients. Methods: A prospective cross sectional study was done in patients who were admitted to a tertiary care hospital with features of dengue fever. A total of 364 patients with IgM dengue serology positive were included in the study. Relevant clinical and laboratory parameters were collected from all patients. Association between clinico-laboratory parameters with mortality was studied using appropriate statistical methods. Results: Among the 364 patients recruited in this study, 14 (3.85%) patients died. Mortality among patients with age group 18-40 years was 2.04%, in patients aged above 40 years was 7.56%. Mortality among patients with hypotension was 42.42% (14 out of 33), bleeding manifestations was 15.38% (8/52), platelets <20,000/mm3 was 10.41% (10/96), ALT >200 was 13.04% (6/46), AST>200 was 12.34% (10/81), prolonged prothrombin time was 60%(12/20), renal failure was 28%(14/50), encephalopathy was 31.57% (6/19), multi organ dysfunction syndrome(MODS) was 43.33% (13/30), acute respiratory distress syndrome (ARDS) was 45.45% (5/11), pleural effusion was 7.5% (6/80). Conclusions: The overall mortality in the present study was 3.85%. Following variables were associated with increased risk of death among the dengue patients: Age >40 years, presence of hypotension, platelets <20000 cells/mm3, ALT>200U/L, AST>200U/L, prolonged prothrombin time, presence of renal failure, encephalopathy, MODS, ARDS and bleeding tendency (p value <0.05). Early identification of factors associated with mortality can help to make appropriate decision on care required.

Item Type: Article
Uncontrolled Keywords: Dengue fever; Mortality predictors; Thrombocytopenia.
Subjects: Medicine > KMC Manipal > Community Medicine
Medicine > KMC Manipal > Medicine
Depositing User: KMC Library
Date Deposited: 22 Jan 2019 09:23
Last Modified: 22 Jan 2019 09:23
URI: http://eprints.manipal.edu/id/eprint/153090

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