siRNA intervention inhibiting viral replication and delivery strategies for treating herpes simplex viral infection

Manda, Vyshnavi and Rao, Venkata J and Hariharapura, Raghu Chandrashekar (2019) siRNA intervention inhibiting viral replication and delivery strategies for treating herpes simplex viral infection. Virus diseases, 9 (30). pp. 1-6. ISSN 2347-3584

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Abstract

The effective treatment of herpes simplex virus (HSV) infections generally involves the use of antiviral nucleoside drugs, but with increasing reports of antiviral resistance, the use of these drugs is challenged. Hence, a need arises to explore alternate treatment options. In this review we have discussed various targets that have been explored to control the HSV replication using siRNA therapeutics. We have also discussed the advantages of targeting a less explored UL10 gene to develop an alternate therapeutic intervention. Gene silencing can induce an inhibitory activity to virus spread and infection. The capacity and suitability of UL10 gene as siRNA induced silencing target in eliciting the desired antiviral effect in patients is identified and particularly discussed. The major challenge associated with the siRNA therapeutics is their delivery. The various viable delivery options, that are being explored in the recent times is summarized and different delivery pathways and strategies are reviewed as a part of the study.

Item Type: Article
Uncontrolled Keywords: Herpes simplex virus; Gene silencing; siRNA; siRNA delivery; UL10 gene
Subjects: Departments at MU > Public Health
Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Depositing User: KMC Library
Date Deposited: 02 Feb 2019 04:09
Last Modified: 02 Feb 2019 04:09
URI: http://eprints.manipal.edu/id/eprint/153142

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