Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats

Reddy, Srinivasa J and Daram, Prasanthi and Rao, Picheswara Polu and Shah, Abhishek and Shreedhara, CS and Lobo, Richard and Gourishetti, Karthik and Misra, CS and Nampoothiri, Madhavan (2019) Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats. Journal of Toxicology, 2019 (1). pp. 1-11. ISSN 16878191

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Abstract

Terminalia tomentosa bark belongs to the family Combretaceae. Te plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea. Phytochemical investigation of T. tomentosa bark confrms the presence of favonoids, polyphenols, and tannins. Te plant has not been investigated for its anti-infammatory and antiarthritic activity. Te present study was undertaken to explore its possible anti-infammatory and antiarthritic activity. Anti-infammatory activity of alcoholic and aqueous extracts of the bark was assessed by in vivo methods. In vivo antiarthritic potential of the extracts was evaluated by Complete Freund’s Adjuvant (CFA) induced arthritis in Wistar rats. Our fndings showed that the alcoholic and aqueous extracts exhibited anti-infammatory activity at 500 mg/kg oral dose in carrageenan-induced hind paw edema and carrageenan-induced air pouch infammation models. We also found alcoholic as well as aqueous extracts of the bark restored the altered blood and serum parameters caused by the Complete Freund’s Adjuvant-induced arthritis in Wistar rats. Tis study shows that the T. tomentosa bark extracts possess anti-infammatory activity and have pronounced efects on adjuvant arthritis also. Future studies are necessary to provide deeper insight into the exact mechanism of the action of anti-infammatory and antiarthritic activity of T. tomentosa.

Item Type: Article
Uncontrolled Keywords: Inflamation; Terminalia tomentosa
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 04 Feb 2019 04:31
Last Modified: 04 Feb 2019 04:31
URI: http://eprints.manipal.edu/id/eprint/153164

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