Nagamma, T (2019) Assessment of oxidative damage and lipid profile levels in tobacco chewers with Type 2 diabetes mellitus. Bangladesh Journal of Medical Science, 18 (1). pp. 78-82. ISSN 2223-4721
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Abstract
Objectives: To assess oxidative damage and lipid profile levels in Type 2 diabetes mellitus patients with or without tobacco chewing habit. Methods: Total of 141 newly diagnosed Type 2 diabetes mellitus patients with tobacco chewing habit from past >18 years were included,136 Type 2diabetes mellitus without any tobacco chewing habit, 140 normal healthy subjects without any tobacco chewing habit were included in the study. Blood sample was collected after 8-12 hours fasting from each subject to estimate glucose and cholesterol. The plasma was used for estimation of total antioxidant (TAA) activity, Vitamin C and thiobarbituric acid reacting substances (TBARS) by standard methods. Statistical analysis was done with SPSS version 16.Results: The glucose, cholesterol and TBARS levels were found to be increased significantly (p<0.001) in diabetic patients with tobacco chewing habit, as well as TAA, Vitamin C levels decreased significantly (p<0.001) when compared with healthy individuals. Conclusion: We observed increased oxidative stress and declined levels of antioxidants in newly diagnosed type 2 diabetes patients with tobacco chewing habit. It is known that hyperglycemia induces oxidative stress and further facilitate the progression of diabetic complications.
Item Type: | Article |
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Uncontrolled Keywords: | Tobacco chewing; Oxidative stress; Antioxidants; Hyperglycemia; Type 2 DM |
Subjects: | Medicine > MMMC Manipal > Biochemistry |
Depositing User: | KMC Library |
Date Deposited: | 08 Feb 2019 08:39 |
Last Modified: | 08 Feb 2019 08:39 |
URI: | http://eprints.manipal.edu/id/eprint/153209 |
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