Concise review: Quiescence in adult stem Cells: Biological significance and relevance to tissue regeneration

Rumman, Mohammad (2015) Concise review: Quiescence in adult stem Cells: Biological significance and relevance to tissue regeneration. Stem Cells, 33. pp. 20-903.

[img] PDF
stem.2056.pdf - Published Version
Restricted to Registered users only

Download (375kB) | Request a copy

Abstract

Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.

Item Type: Article
Uncontrolled Keywords: Adult stem cells; cell cycle; quiescence; hematopoietic stem cells; marrow stromal cells; muscle stem cells; differentiation.
Subjects: Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 19 Mar 2019 06:10
Last Modified: 19 Mar 2019 06:10
URI: http://eprints.manipal.edu/id/eprint/153442

Actions (login required)

View Item View Item