Design of multifunctionalized piperazine polymer and its activity toward pathogenic microorganisms

Manohara, D J and Yashoda, M P and Ajithkumar, M P and Ananda, K (2019) Design of multifunctionalized piperazine polymer and its activity toward pathogenic microorganisms. Journal of Applied Polymer Science, 136 (19). pp. 47521-47533. ISSN 1097-4628

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Abstract

The study intends to design a simple and powerful synthesis of piperazine-methacrylate monomer and its homopolymer. The synthesized piperazine-methacrylate monomer was polymerized by solution polymerization technique in the presence of freeradical initiator azobi (2-methylpropionitrile) resulting in the formation of multifunctionalized piperazine polymer. The structural investigation was done by FTIR and NMR (1H and 13C NMR). The thermal properties and degradation of the polymer were examined by DSC and TGA techniques. The polymer exhibited glass transition temperature (Tg) at 88.4 �C. The polymer surface was found to be soft and nonporous which was examined by FESEM. The synthesized polymeric compound exhibited good antimicrobial activity against Gram-negative bacterium Escherichia coli, tubercular variant Mycobacterium smegmatis, and Gram-positive bacterium Staphylococcus aureus with a zone of inhibition at a range of 15.60–19.33, 15.33–17, and 15.67–18 mm diameter, respectively. The polymer also showed good activity against fungus Candida albicans with a zone of inhibition at a range of 16.33–22 mm diameter. The percentage inhibition of microorganisms increased with increase in concentration (1.5–12 mg) which is carried out by optical density method. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47521.

Item Type: Article
Uncontrolled Keywords: antimicrobial screening; multifunctionalized piperazine polymer; polymer characterization
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 19 Mar 2019 06:56
Last Modified: 19 Mar 2019 06:56
URI: http://eprints.manipal.edu/id/eprint/153450

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