Implication of critical pharmacokinetic gene variants on therapeutic response to metformin in Type 2 diabetes

Phani, Nagaraja M and Vohra, Manik and Kakar, Ananth and Shivashankara, KN and Shashikiran, U and Satyamoorthy, K and Rai, Padmalatha S (2018) Implication of critical pharmacokinetic gene variants on therapeutic response to metformin in Type 2 diabetes. Pharmacogenomics, 19 (11). pp. 905-911. ISSN 1462-2416

[img] PDF
00006340.pdf - Published Version
Restricted to Registered users only

Download (351kB) | Request a copy

Abstract

Aim: Metformin, an oral hypoglycemic drug is the first line of treatment for Type 2 diabetes individuals. We studied the effect of critical gene single nucleotide polymorphisms on the glucose lowering effect of metformin. Method: We performed a prospective study on 221 newly diagnosed, treatmentnaive Type 2 diabetes subjects. Individuals were started with metformin monotherapy and followed up for 12 weeks. Results: Our association analysis revealed that SLC22A2 rs316019 and SLC47A2 rs12943590 were significantly associated with metformin drug response across co-dominant and dominant models, respectively. SLC22A2 rs316019 GG and SLC47A2 rs12943590 GA combined genotypes showed maximum average change in HbA1c level. Conclusion: The present study proposes a role of SLC22A2 rs316019 and SLC47A2 rs12943590 in the pharmacokinetic action of metformin.

Item Type: Article
Uncontrolled Keywords: Metformin ; multidrug and toxin extrusion ; organic cation transporter ; pharmacogenomics ;pharmacokinetics ; Type 2 diabetes.
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Medicine
Depositing User: KMC Library
Date Deposited: 26 Mar 2019 09:58
Last Modified: 26 Mar 2019 09:58
URI: http://eprints.manipal.edu/id/eprint/153515

Actions (login required)

View Item View Item