Development and validation of diclofenac sodium in tablets using simple UV spectrophotometric method

Mane, Ragini V and Patel, Kritika and Gude, Sushmitha Sai and Vasantharaju, SG (2019) Development and validation of diclofenac sodium in tablets using simple UV spectrophotometric method. Research Journal of Pharmacy and Technology, 12 (2). pp. 611-614. ISSN 0974-3618

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Abstract

An effective and simple UV-Spectrophotometric method was developed and validated for the quantification of Diclofenac sodium in tablets. The maximum absorption was found to be 282nm by using methanol as the solvent. The linearity range was 6-21 μg/ml and the correlation coefficient (r²) was found to be 0.9985. The method was accurate, precise, and robust with %RSD below 2%. The LOD and LOQ was found to be 0.0885μg/Ml and 0.250μg/mL respectively. Sandel’s sensitivity was found to be 0.000002 μg/mL. Assay and accuracy of the tablets were about of the acceptance criteria range as per the ICH guidelines.

Item Type: Article
Uncontrolled Keywords: U V spectrometry; diclofenac sodium; tablets; validation; ICH guidelines.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Depositing User: KMC Library
Date Deposited: 01 Apr 2019 04:04
Last Modified: 01 Apr 2019 04:04
URI: http://eprints.manipal.edu/id/eprint/153558

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