Local Recurrence and Survival Among Black Women With Early-Stage Breast Cancer Treated With Breast-Conservation Therapy or Mastectomy

Lisa A. Newman, MD and Henry M. Kuerer, MD and Kelly K. Hunt, K and Gurpreet Singh, H (1999) Local Recurrence and Survival Among Black Women With Early-Stage Breast Cancer Treated With Breast-Conservation Therapy or Mastectomy. Local Recurrence and Survival Among Black Women With, vol (6). pp. 241-248. ISSN -

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Abstract

Background: Black women with breast cancer have significantly worse survival rates and receive diagnoses at relatively younger ages, compared with white patients with breast cancer, in the United States. Young age at diagnosis has been associated with increased risk for local recurrence (LR) after breast-conservation therapy (BCT). The goal of this study was to evaluate the impact of age and BCT on LR and survival rates among black patients with breast cancer. Methods: The records for 363 black women treated for breast cancer (excluding stage IV disease) at a comprehensive cancer center were reviewed. Results: Fifty-eight percent of patients (n � 211) had tumors �5 cm in diameter. Forty-two of these patients (19.9%) received BCT; the LR rate for this group was 9.8%. A total of 168 patients (79.6%) underwent mastectomy; the LR rate for this group was 8.9%. Data on the primary operation were unavailable for one patient. Five-year disease-free survival rates were similar for patients treated with BCT and those treated with mastectomy (88% and 73%, respectively). LR was associated with significant decreases in 5-year overall survival rates for both the BCT group (67% vs. 95%, P � .01) and the mastectomy group (43% vs. 76%, P � .01). LR and 5-year diseasespecific survival rates were similar for patients �50 years of age and patients �50 years of age, regardless of treatment. Conclusions: LR and survival rates are not compromised by the use of BCT among black American patients. LR is associated with an increased risk of breast cancer death, regardless of treatment type. Younger age at diagnosis was not associated with an increased rate of LR after BCT in this serie

Item Type: Article
Subjects: Allied Health > Bangalore Campus > Physiotherapy
Depositing User: KMC LIB
Date Deposited: 17 Apr 2019 03:36
Last Modified: 17 Apr 2019 03:37
URI: http://eprints.manipal.edu/id/eprint/153591

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