Evaluation of biodegradable gel containing flax seed extract (Linum usitatissimum) as a targeted drug delivery for management of chronic periodontitis

Pappu, R and Varghese, Jothi M and Koteshwara, KB and Lobo, Richard and Nimmy, K (2019) Evaluation of biodegradable gel containing flax seed extract (Linum usitatissimum) as a targeted drug delivery for management of chronic periodontitis. Journal of Herbal Medicine, 15. pp. 1-7. ISSN 2210-8033

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Abstract

Treatment of periodontitis has been one of the most challenging aspects of periodontal therapy. The role of host immune inflammatory response in periodontal disease forms the basis of modernistic therapeutic approaches.The present study evaluates the efficacy of an indigenously formulated flax seed extract in the form of biodegradable gel, as an adjunct in the treatment of chronic periodontitis. Sixty patients diagnosed with localized periodontal disease having pocket probing depth ≥ 5mm were selected. All the patients were treated with professional oral prophylaxis and root instrumentation as part of the standard periodontal care protocol. The participants were divided into 3 groups with 20 subjects in each group. One group received the formulated flax seed extract gel and second group received flurbiprofen gel. The third and/or control group did not receive any adjunct therapy. The following measurements were recorded at baseline, first and third month, which included,Gingival crevicular fluid (GCF) and saliva samples for estimation of drug release followed by record of clinical parameters i.e. plaque index, gingival index, pocket probing depth and clinical attachment levels. The results of the study demonstrated that the flax seed extract gel could be equally associated to the effectiveness of flurbiprofen gel, at the end of 90 days (p=0.001). Hence, this randomized clinical trial sets a route for incorporating herbal constituents as targeted drug therapeutic agents for the management of chronic periodontitis. Also, the use of these phytotherapeutic agents can be further encouraged considering its safety, low risk and economical options.

Item Type: Article
Uncontrolled Keywords: Flax seed extract gel; Flurbiprofen gel; Omega- 3 fatty acid; Chronic periodontitis; Gingival crevicular fluid; Saliva
Subjects: Dentistry > MCODS Manipal > Periodontology
Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Library
Date Deposited: 02 May 2019 05:52
Last Modified: 02 May 2019 05:52
URI: http://eprints.manipal.edu/id/eprint/153757

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