Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot Study

*, Alam Nawaz and Srinivas Nayak Manel, Arjun and Thakur Hameer, Subhangi and Kamath, Ashwin and Mahale, Ajit (2019) Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot Study. Indian Journal of Medical Specialities, 10 (2). pp. 99-104. ISSN 0976-2892

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Abstract

Background: We aimed to determine if serum cholesterol and body mass index (BMI), which are important in maintaining immunity, have any impact on the radiological severity in patients with drug‑resistant pulmonary tuberculosis (DR‑TB). Materials and Methods: A cross‑sectional pilot study was conducted over 2 years in adults with newly diagnosed DR‑TB. The radiological severity of the disease was determined using a chest X‑ray (CXR) scoring formula. Correlation between the lipid fraction levels, BMI, and the CXR scores was determined using Pearson’s correlation coefficient. Results: Thirty‑three patients were included in the study. A significant negative correlation was seen between the CXR severity scores and total cholesterol (r = −0.546, P = 0.001), high‑density lipoprotein‑cholesterol (r = −0.479, P = 0.005), low‑density lipoprotein‑cholesterol (r = −0.431, P = 0.012), and BMI (r = −0.352, P = 0.044). Conclusions: Low serum cholesterol levels and low BMI were associated with an increased radiological severity which, in turn, could result in increased infectivity. Adequate nutritional supplementation in the diet of patients to increase BMI, and serum cholesterol levels, could potentially decrease the severity, and also consequently, transmission, and incidence of DR‑TB.

Item Type: Article
Uncontrolled Keywords: Cholesterol, drug-resistant tuberculosis, infection transmission, radiography
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Radio Diagnosis and Imaging
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 29 May 2019 09:54
Last Modified: 29 May 2019 09:54
URI: http://eprints.manipal.edu/id/eprint/153912

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