Clinicopathological study of primary focal segmental glomerulosclerosis: A new vision of all variants

Mathew, Mary (2016) Clinicopathological study of primary focal segmental glomerulosclerosis: A new vision of all variants. Annals of Pathology and Laboratory Medicine, 3 (4). A-296. ISSN 2394-6466

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Abstract

Background: This study is a detailed clinical and histomorphological analysis of Primary Focal Segmental Glomerulosclerosis diagnosed by combined approach of histopathology and direct immunofluorescence. The aim was to identify the morphologic variants with histopathological prognostic features of primary focal segmental glomerulosclerosis and to establish the clinical, laboratory & pathologic findings in nephrotic syndrome & renal insufficiency associated with primary focal segmental glomerulosclerosis. Methods: It was a prospective & retrospective analysis of 41 cases of primary Focal Segmental Glomerulosclerosis. Routine & special stains were done all renal biopsies. Immunofluorescence studies were performed. Multiple comparisons among the groups were performed using ANOVA. Mean comparison of two groups was performed using independent sample t-test. A categorical variable was tested using Chi-square test and fishers exact test. Results: Out of 718, all the 41 renal biopsies of primary FSGS classified into morphologic variants. Primary Focal segmental glomerulosclerosis constituted 5.7% of total kidney biopsies. Mean age was 35.93 years having male preponderance. Proteinuria was highest in Perihilar variant while hematuria was more in the cellular variant. Nephrotic syndrome was most commonly associated with the cellular and perihilar variant. It was only histological parameter whose distribution among the different variants was statistically significant. A statistically significant correlation (p<0.05) was noted between the percentage of globally sclerosed glomeruli with hypertension & serum creatinine. A significant correlation was found between serum creatinine and mesangial hypercellularity, serum albumin, podocyte hyperplasia, arteriolar hyalinosis, intimal sclerosis and medial hypertrophy. Conclusions: This comprehensive study of primary FSGS reiterates that different histological variants of FSGS have substantial differences in clinical and histological features.

Item Type: Article
Uncontrolled Keywords: Primary focal segmental glomerulosclerosis; immunofluorescence; nephrotic syndrome; variant.
Subjects: Medicine > KMC Manipal > Pathology
Depositing User: KMC Library
Date Deposited: 29 Jul 2019 03:48
Last Modified: 29 Jul 2019 03:48
URI: http://eprints.manipal.edu/id/eprint/154150

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