Multiple oncogenic roles of nuclear b-catenin

Kumar, Raju (2017) Multiple oncogenic roles of nuclear b-catenin. Journal of Biosciences, 42 (4). pp. 695-707. ISSN 0250-5991

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Abstract

b-Catenin is essential for embryonic development and required for cell renewal/regeneration in adult life. Cellular b- atenin exists in three different pools: membranous, cytoplasmic and nuclear. In this review, we focus on functions of the nuclear pool in relation to tumorigenesis. In the nucleus, b-catenin functions as both activator and repressor of transcription in a context-dependent manner. It promotes cell proliferation and supports tumour growth by enhancing angiogenesis.b-Catenin-mediated signalling regulates cancer cell metabolism and is associated with tumour-initiating cells in multiple malignancies. In addition, it functions as both pro- and anti-apoptotic factor besides acting to inhibit recruitment of inflammatory anti-tumour T-cells. Thus, b-catenin appears to possess a multifaceted nuclear function that may significantly impact tumour initiation and progression

Item Type: Article
Uncontrolled Keywords: Anti-tumour immunity; Cancer cell metabolism; Epithelial-mesenchymal transition; Tumour-initiating cells; Tumour micro-environment
Subjects: Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 06 Aug 2019 03:50
Last Modified: 06 Aug 2019 03:50
URI: http://eprints.manipal.edu/id/eprint/154240

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