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Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice

Jagannath Poojary, Roopesh and *, Nayanatara AK and *, Reshma Kumarachandra and *, Vinodini N.A and *, Bhagyalakshmi K and *, Ganesh Sanjeev (2019) Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice. Asian Pacific Journal of Tropical Biomedicine, 9 (7). pp. 278-283. ISSN 22211691

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Abstract

Objective: To explore the effect of hydroalcoholic extract of Cynodon dactylon on the whole body radiation-induced oxidative status of the cerebellum and cognitive impairments in mice. Methods: Swiss albino mice were randomly divided into the control group, radiation control group, low dose and high dose Cynodon dactylon extract treated groups and pre-treated with Cynodon dactylon extract before irradiation. Cynodon dactylon extract was administered for 7 d daily in low dose (0.25 g/kg) and high dose (1 g/kg). On day 7, mice were irradiated with a sublethal dose of 5 Gy gamma rays. Motor coordination was assessed by elevated rotarod test and spatial memory was studied by water maze test. Subsequently, biochemical markers (glutathione, lipid peroxidation and nitric oxide levels) in the cerebellum were evaluated. Results: The gamma irradiated group showed significant impairment in motor coordination and spatial memory compared to normal mice. Mice treated by Cynodon dactylon extract prior to gamma radiation showed good improvement in both paradigms compared to the radiation control group. Moreover, glutathione level was increased, while lipid peroxidation and nitric oxide levels were significantly reduced in mice receiving low dose and high dose of Cynodon dactylon extract compared to the radiation control group. Conclusions: The present study suggests the neuroprotective role of Cynodon dactylon against radiation-induced cognitive impairment and oxidative stress on the cerebellum of mice.

Item Type: Article
Uncontrolled Keywords: Cerebellum Radiation Cognition Cynodon dactylon Memory
Subjects: Medicine > KMC Mangalore > Physiology
Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 23 Jul 2019 06:43
Last Modified: 23 Jul 2019 06:43
URI: http://eprints.manipal.edu/id/eprint/154246

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