Is lead in nagabhasma toxic to liver? – A histological evaluation

Andrade, Lydia S (2019) Is lead in nagabhasma toxic to liver? – A histological evaluation. European Journal of Anatomy, 23 (4). pp. 267-272. ISSN 2340-311X

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Abstract

Ayurvedic medicines is known to use heavy met-als in their preparation. Nagabhasma is one such form of a lead-based medicine. Even though lead is known to be toxic to several systems of the hu-man body, according to Ayurveda, the metallic tox-icity of the lead gets nullified and thereby imbibes medicinal property when it is prepared using many herbs and stringent traditional methods. Therefore, the present study is designed to evaluate the effect of such detoxified lead in various stages of authen-tically prepared Nagabhasma on the histopatholo-gy of liver in comparison with lead acetate and commercially available Nagabhasma-administered animals. Less than the human-equivalent doses of Nagabhasma at four intermittent stages of its prep-aration were administered orally for 30 days and 60 days (short term and long term exposure) to Wistar rats. In another set of experiment, test-material-administered animals were kept under observation for an additional period of two months to record the residual effect. Immediately after the administration and after the observation period, the animals were sacrificed to collect the liver for histo-pathological examination. The histopathological results of the immediate and residual effects showed varying alterations in the microarchitecture of the liver as the stages of Nagabhasma preparation advanced. The final product (stage 4 bhasma), showed very less toxic effect in comparison with other stages. In conclu-sion, the results state that, by following the tradi-tional procedures while preparing Nagabhasma the metallic lead gets converted into non-toxic organometallic compound.

Item Type: Article
Uncontrolled Keywords: Ayurveda ; Lead toxicity ; Histology ; Hepatocytes ; Sinusoids.
Subjects: Medicine > KMC Manipal > Anatomy
Depositing User: KMC Library
Date Deposited: 06 Aug 2019 05:50
Last Modified: 06 Aug 2019 05:50
URI: http://eprints.manipal.edu/id/eprint/154261

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