Roles of contrast‑enhanced ultrasound and diffusion‑weighted magnetic resonance imaging and their comparison in solid space‑occupying lesions of the liver – Microbubbles and micromovements in imaging

Rai, Santosh PV and Reddy, Tejasvi Bobbili and Gopal, Sandeep and Shenoy, Suresh (2019) Roles of contrast‑enhanced ultrasound and diffusion‑weighted magnetic resonance imaging and their comparison in solid space‑occupying lesions of the liver – Microbubbles and micromovements in imaging. West African Journal of Radiology, 26 (2). pp. 69-79. ISSN 1115-1474

[img] PDF
Roles of contrast-enhanced ultrasound and diffusion-weighted magnetic resonance imaging and their comparison in solid space-occupying lesions of the liver – Microbubbles and micromovements in imaging..pdf - Published Version
Restricted to Registered users only

Download (5MB) | Request a copy

Abstract

Aims: This study aims to establish the role of contrast-enhanced ultrasound (CEUS) and diffusion-weighted (DW) magnetic resonance imaging (MRI) in the characterization of solid liver lesions.Settings and Design: An analysis of 22 patients undergoing CEUS and DW MRI following identification of 1 or more solid liver lesions on conventional ultrasonography.Subjects and Methods: The study is carried in a standard Doppler ultrasound machine with contrast ultrasound capabilities and 1.5T MRI machine over a period of 2 years from July 2015 to June 2017. After baseline US examination, a bolus of 1.0–2.4 ml of ultrasound contrast agent was administered intravenously followed by 10 ml of saline flush. CEUS images were obtained during arterial, portal venous, and delayed phases. After CEUS, patient is transferred to MRI scanning room where the DW imaging (DWI) sequence is taken. The CEUS and DW MRI diagnosis were compared to other imaging modalities, histopathology, and/or clinical follow-up after 12 months.Statistical Analysis Used: Sensitivity, specificity, positive predictive value, negative predictive value, accuracy rate and receiver operating characteristic analysis curve was performed using Statistical Package – SPSS ver. 17.0. Statistical evaluation of qualitative analysis between benign and malignant lesions was performed using the Fisher’s exact test.Results: CEUS correctly identified malignant liver lesions in 13 out of 14 cases, with the final diagnosis confirmed by histopathology in 6 cases, by other imaging modalities in 7 cases and follow-up in 1 case. Eight patients were correctly identified as benign liver lesions on CEUS imaging, with all these cases confirmed on other imaging modalities and/or follow-up and two cases by histopathology. In the detection of malignancy, the sensitivity is 86.7% and specificity is 100%. On the DW images the Mean apparent diffusion coefficient (ADC) value for benign lesions is 1.5 and mean ADC value for malignant lesions is 0.7. The ADC was significantly higher in benign lesions than in malignant lesions (P < 0.01).

Item Type: Article
Uncontrolled Keywords: Contrast-enhanced ultrasound, diffusion-weighted magnetic resonance imaging, liver
Subjects: Medicine > KMC Mangalore > Gastroenterology
Medicine > KMC Mangalore > Radio Diagnosis and Imaging
Depositing User: KMCMLR User
Date Deposited: 29 Jul 2019 09:39
Last Modified: 29 Jul 2019 09:39
URI: http://eprints.manipal.edu/id/eprint/154277

Actions (login required)

View Item View Item