Local drug delivery systems in the management of periodontitis: A scientific review

Rajeshwari, HR and Rao, Meghana (2019) Local drug delivery systems in the management of periodontitis: A scientific review. Journal of Controlled Release, 307. pp. 393-409. ISSN 0168-3659

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Abstract

Periodontitis (PD) is a microbial disease of tooth supporting tissues that results in progressive destruction of surrounding soft and hard tissues with eventual tooth mobility and exfoliation. Perioceutics, which includes the delivery of therapeutic agents via systemic and local means as an adjunct to mechanical therapy has revolutionized the arena of periodontal therapy. Selection of a right antimicrobial agent with appropriate route of drug administration is the key to successful periodontal therapy. Irrigating systems, fibers, gels, strips, films,microparticles, nanoparticles and low dose antimicrobial agents are some of the local drug delivery systems (LDDS) available in the field, which aims to deliver antimicrobial agents to sub-gingival diseased sites with minimal or no side-effects on other body sites. The present review aim to summarize the current state-of-the-art technology on LDDS in periodontal therapy ensuring the the practitioners are able to choose LDD agents which are custom made for a specific clinical condition

Item Type: Article
Uncontrolled Keywords: Local drug delivery systems; Periodontitis; Antimicrobial agents; Perioceutics
Subjects: Dentistry > MCODS Manipal > Conservative Dentistry and Endontics
Dentistry > MCODS Manipal > Periodontology
Depositing User: KMC Library
Date Deposited: 12 Aug 2019 04:06
Last Modified: 12 Aug 2019 04:06
URI: http://eprints.manipal.edu/id/eprint/154325

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