Solubility and Dissolution Improvement of Carbamazepine by Various Methods

Shreya, * and Heena, Ayesha and Ranjitha, * and Shetty, Amrutha A and Mehta, Chetan H and Nayak, Usha Y and Mutalik, Srinivas and Pai, Girish K (2019) Solubility and Dissolution Improvement of Carbamazepine by Various Methods. Research Journal of Pharmacy and Technology, 12 (7). pp. 3333-3337. ISSN 0974-360X

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This work was aimed to improve solubility and dissolution rate of carbamazepine (CBZ), an antiepileptic, BCS class II drug by using different solubility enhancement techniques. Self-nanoemulsifying drug delivery system (SNEDDS) and solid dispersions of CBZ was attempted by spontaneous emulsification method and fusion method, respectively. The solubility studies of pure CBZ was performed in different oils, surfactants and co-surfactants. Very small amount of CBZ (20 mg) could be incorporated in SNEDDS, however the solid dispersion of CBZ using Soluplus® was successfully prepared with the required dose. The solid dispersion was characterized and evaluated for saturation solubility, in vitro dissolution studies, solid state characterization such as fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction studies (XRD). Based on the results, it can be concluded that the due to increased solubility and the dissolution, the bioavailability of CBZ could be improved by preparing solid dispersion

Item Type: Article
Uncontrolled Keywords: Carbamazepine; Self-nanoemulsifying drug delivery system; Solid dispersion; Spontaneous emulsification method; Fusion method
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 18 Aug 2019 04:24
Last Modified: 18 Aug 2019 04:24

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