Experimental data of fabricated co-crystals of doxorubicin hcl with flavonoids

Laxmi, Prasanna and Varma, Abhishek and Pai, Aravinda and Sathyanarayana, Muddukrishna Badamane (2019) Experimental data of fabricated co-crystals of doxorubicin hcl with flavonoids. Indian Journal of Pharmaceutical Education and Research, 53 (3). S225-S230. ISSN 0019-5464

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Abstract

Objectives: This current research work aimed for improvement of the solubility and permeability of poorly permeable Doxorubicin HCl through generating co-crystals. The main goal for the preparation of oral drugs is to decrease the overall cost of healthcare and route of administration is made easy. Methodology: In this study co-crystals of Doxorubicin HCl with Quercetin hydrate and Naringin has been prepared based on ease of hydrogen bond formation. The co-crystal batches of Doxorubicin HCl-Quercetin hydrate in ratio 1:1, 1:2, 2:1 and Doxorubicin HCl-Naringin in ratio 1:1 are prepared by slow solvent evaporation technique. Results and Discussion: The formation of co-crystal was confirmed by PXRD, DSC and FTIR. Doxorubicin HCl with Naringen crystal batch show improved solubility. The dynamic solubility of Doxorubicin HCl-Naringin co-crystal in the ratios 1:1 increased by approximately 9.2-fold as compared to pure drug and Doxorubicin HCl -Quercetin hydrate cocrystal batches.

Item Type: Article
Uncontrolled Keywords: Doxorubicin HCl; Quercetin hydrate; Naringin; Cocrystals; HPLC; Solid state characterisation; Saturated solubility.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Depositing User: KMC Library
Date Deposited: 17 Aug 2019 03:58
Last Modified: 17 Aug 2019 03:58
URI: http://eprints.manipal.edu/id/eprint/154408

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