Clinical and equipment-related factors associated with the adequateperipheral blood stem cell collection in autologous transplant at a tertiarycancer center in Kerala - A retrospective cohort study

Rathi, Priya and m, Murugesan and k, Shringarpure and D.S.A, Karthickeyan and Nair, C.K and S.K, Nayanar and V, Venugopal and K, Selvaraj and K.G, Metha and V, Deenathayalan and G.K, Chellaiya (2019) Clinical and equipment-related factors associated with the adequateperipheral blood stem cell collection in autologous transplant at a tertiarycancer center in Kerala - A retrospective cohort study. Transfusion and Apheresis Science, 58 (2019). pp. 457-463. ISSN 1473-0502

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Abstract

Background:PBSC collection using apheresis is the preferred source of hematopoietic stem cells transplantation.However, apheresis procedures fail to harvest adequate CD34 yield in 5 to 40% of patients during thefirstcollection. Therefore, this study aimed to study both the clinical- and equipmentrelated factors influencing CD34yield among the autologous patients and to compare the collection efficiency of two apheresis equipments(Haemonetics MCS+ and Terumo Spectra Optia).Methods:Retrospective analysis of 69 patients underwent PBSC collection from 2015 to 2018. Frequency,clinical- and equipment-related factors responsible for adequate CD34+ cells (≥2 x106 cells/kg) yield duringthefirst collection was studied. Factors such as collection efficiency, percentage platelet loss and percentagehemoglobin loss were considered to compare the two apheresis system.Results:Two-third (72%) patients of the study population had adequate CD34 stem cells yield during thefirstcollection. Factors such as exposure to lenalidomide-based pretreatment regimen, peripheral blood WBC countand CD34 count are associated with the adequate CD34 yield. Optia had a slightly better collection efficiencythan MCS+ (50 and 44; p=0.37). Optia had lower product volume (237 vs 298 ml) and lesser procedureduration (277 vs 360 min), whereas the median Hb loss (3.0% and 2.3%) and mean platelet loss (49% and 34%)were higher with MCS.Conclusion:This study infers that the collection efficiency of both the equipments in collecting CD34 stem cellswas similar. However, during PBSC collection, procedures using Optia can be preferred to MCS+ on the patientswith risk of anemia and thrombocytopenia

Item Type: Article
Uncontrolled Keywords: ApheresisCD 34 yieldPBSCCollection Efficiency (CE)Platelet lossSORT-IT
Subjects: Medicine > KMC Mangalore > Community Medicine
Depositing User: KMCMLR User
Date Deposited: 26 Aug 2019 10:46
Last Modified: 26 Aug 2019 10:46
URI: http://eprints.manipal.edu/id/eprint/154442

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