Effect of Green Tea Extract (Camelia sinensis) on Spatial Learning and Memory in REM sleep deprived Albino Wistar Rats

Nayak, Veena and Mamulpet, Vinay and Bairy, KL and Poojar, Basavaraj and Balaji, O (2019) Effect of Green Tea Extract (Camelia sinensis) on Spatial Learning and Memory in REM sleep deprived Albino Wistar Rats. British Journal of Bio-Medical Research, 3 (1). pp. 805-814. ISSN 2456-9739

[img] PDF
7126 DisplayPdf.pdf - Published Version
Restricted to Registered users only

Download (434kB) | Request a copy

Abstract

Introduction: Sleep deprivation can enhance the metabolic rate and oxidative stress, causing memory deficits. Green tea (Camellia sinensis), has shown to have radical scavenging, gene modulating, and cell signalling activities rendering it to have neuroprotective action.Objective: To evaluate the possible beneficial effect of aqueous extract of green tea (GTE) on spatial learning and memory in rapid eye movement (REM) sleep deprived rats.Methodology: Wistar albino rats were deprived of REM sleep for 96 h using the modified inverted flowerpot technique. Morris water maze, antioxidants levels and body weight were used to assess cognitive enhancing and metabolic activity.Results: Increase in oxidative stress following REM sleep deprivation was reversed in both acute and chronic study. Chronic intake of GTE mitigated spatial learning and memory deficit in Wistar rats induced by REM sleep deprivation.Conclusion: Oxidative stress is associated with memory deficits induced by sleep deprivation in the present study.

Item Type: Article
Uncontrolled Keywords: REM sleep; Spatial learning and memory; Green tea Extract; Morris water maze
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 13 Sep 2019 05:47
Last Modified: 13 Sep 2019 05:47
URI: http://eprints.manipal.edu/id/eprint/154499

Actions (login required)

View Item View Item