Effectiveness of exercise-based rehabilitation on functional capacityand quality of life in head and neck cancer patients receivingchemo-radiotherapy

Samuel, Stephen Rajan and Maiya, Arun G and Fernandes, Donald J and Guddattu, Vasudeva and Saxena, Prakash P U and Rachel Kurian, Jestina and Ju Lin, Po and M. Mustian, Karen (2019) Effectiveness of exercise-based rehabilitation on functional capacityand quality of life in head and neck cancer patients receivingchemo-radiotherapy. Supportive Care in Cancer, 27 (10). pp. 3913-3920. ISSN ISSN 0941-4355

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Abstract

PurposeFatigue, decreased functionality, and impaired quality of life are some of the most common adverse outcomes of chemo-radiotherapy (CRT). Head and neck cancers (HNC) affect more than half a million individuals globally and its treatment takes aheavy toll on the patient, often affecting their speech, swallowing, and respiratory functions, and as a result they often developfatigue, depression, and physical inactivity. The purpose of this study was to evaluate the effectiveness of exercise-basedrehabilitation on functional capacity, quality of life, fatigue, hemoglobin, and platelet counts in patients with HNC on CRT.Patients and methodsA randomized controlled trial was conducted on 148 patients with head and neck cancer undergoing CRTto evaluate the effectiveness of exercise on functional capacity measured by the 6-min walk test, quality of life measured by theMedical Outcomes Survey Short Form 36 v2 questionnaire, fatigue by the NCCN (0–10) scale, hemoglobin, and platelets. Thecontrol group received standard physical activity recommendations while the exercise group received a structured exerciseprogram of aerobic and active resistance exercises for a period of 11 weeks.ResultsThere was a significant improvement in the functional capacity (p< 0.001), quality of life (p< 0.001), and prevention ofworsening of fatigue (p< 0.001) in the exercise group. The blood parameters did not show a significant difference between thecontrol group and the exercise group.ConclusionOur results elucidate that an 11-week structured exercise program for HNC patients receiving CRT helps in improv-ing their functional capacity and quality of life. It also prevents deterioration of fatigue levels in the exercise group.

Item Type: Article
Uncontrolled Keywords: Exercise Cancer rehabilitation Head and neck cancer Chemo-radiotherapy Functional capacity Quality of life
Subjects: Allied Health > Mangalore Campus > Physiotherapy
Medicine > KMC Mangalore > Radiotherapy and Oncology
Depositing User: KMCMLR User
Date Deposited: 19 Sep 2019 08:09
Last Modified: 19 Sep 2019 08:09
URI: http://eprints.manipal.edu/id/eprint/154604

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