A correlative study of serum ischemia modified albumin and total thiol in prediabetes and diabetes mellitus

Pande, Aashay Prasad and Shenoy, Vijetha Belle and Datta, Divya and Khan, Nadeem G and Ramya, KR (2019) A correlative study of serum ischemia modified albumin and total thiol in prediabetes and diabetes mellitus. International Journal of Clinical Biochemistry and Research, 6 (3). pp. 380-383. ISSN 2394-6369

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Abstract

Introduction: Ischemia is a worldwide scare and denotes decreased oxygen supply to various tissues of our body. Ischemia modified albumin, a biomarker to diagnose cardiac ischemia has a role in oxidative stress. Diabetes mellitus carbohydrate metabolic disorder is an oxidative stress condition. Total Thiol is an antioxidant, which reduces the reactive oxygen species. There have been lot of research which proved the association of diabetes with ischemia modified albumin. In this study we tried to compare the association of ischemia modified albumin with prediabetes as well as diabetes. Materials and Methods: After obtaining the ethical approval from institutional ethics committee, 120 serum samples were collected (40 - normal healthy subjects, 40 - prediabetes, 40 - diabetes mellitus) and analyzed for ischemia modified albumin using spectrophotometric Co(II)-albumin binding assay and total Thiol was measured using spectrophotometric method. Glycated hemoglobin, lipid profile values were obtained from laboratory information system. Data were compiled and appropriate statistical tests were used wherever necessary. p value <0.05 was said to be significant. Result: This study reported decreased levels of ischemia modified albumin and increased levels of total thiol in both prediabetes as well as diabetes mellitus as compared to normal control. Significant positive correlation between ischemia modified albumin and total thiol was obtained. Conclusion: Oxidative stress maker IMA can be neutralized by an anti-oxidant total thiol. People consume antioxidant to prevent progression of chronic diseases. Extra supplementation of antioxidant may not be much helpful in cases where naturally antioxidants are produced due to the diseases. Thus measuring both helps in prevention of extra supplementation of anti-oxidants.

Item Type: Article
Uncontrolled Keywords: Ischemia modified albumin; total thiol; prediabetes; diabetes mellitus; lipid profile; glycated hemoglobin.
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Library
Date Deposited: 05 Oct 2019 04:30
Last Modified: 05 Oct 2019 04:30
URI: http://eprints.manipal.edu/id/eprint/154673

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