Solubility Enhancement of Ticagrelor by Co-Crystal Technology: Preparation, Solid State Characterization and Solubility Studies

Shane, Nazare Lobo John and Pai, Aravind and Pai, Girish K and Pai, Vasudev and Vasanthraju, SG and Muddukrishna, BS (2019) Solubility Enhancement of Ticagrelor by Co-Crystal Technology: Preparation, Solid State Characterization and Solubility Studies. Latin American Journal of Pharmacy, 38 (10). pp. 2051-2056. ISSN 0326-2383

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Abstract

SUMMARY. In this study a new co-crystal of ticagrelor with quercetin has been fabricated with improved solubility. Ticagrelor is a class VI drug with poor solubility and permeability; hence an attempt has been made to improve its solubility by co-crystallization technology. A co-crystal is a structurally homogeneous crystalline material containing an active pharmaceutical ingredient and the co-former in definite stoichiometric amounts. In this study the conformer selected was quercetin based on ease of hydrogen bond formation and also as quercetin will provide a synergistic effect with ticagrelor. The co-crystal of ticagrelor with quercetin was prepared in two ratios (1:1, 2:1). Ticagrelor formed stable co-crystals in the ratios 1:1 and 2:1. The formation of co-crystal was confirmed by PXRD, DSC, and FTIR. The dynamic solubility of co-crystals in the ratios 1:1 and 2:1 increased by approximately 1.6 fold as compared to pure drug

Item Type: Article
Uncontrolled Keywords: Co-crystal; Ticagrelor; Dynamic solubility; Quercetin; Slow evaporation method
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Library
Date Deposited: 05 Oct 2019 05:14
Last Modified: 05 Oct 2019 05:14
URI: http://eprints.manipal.edu/id/eprint/154707

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