Characterization ofPlasmodium vivax pvmdr1Polymorphisms in Isolates from Mangaluru, India

Tacoli, Costanza and Gai, Prabhanjan P. and Siegert, Konrad and Wedam, Jakob and Kulkarni, Suyamindra S. and Rasalkar, Rashmi and Boloor, Archith and Jain, Animesh and *, Chakrapani M and Baliga, Shantaram B and Shenoy, Damodara and Gai, Pramod and Devi, Rajeshwari (2019) Characterization ofPlasmodium vivax pvmdr1Polymorphisms in Isolates from Mangaluru, India. American Journal of Tropical Medicine and Hygiene, 101 (2). pp. 416-417. ISSN 0002-9637

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Abstract

India accounts for approximately half of the globalPlasmodium vivaxcases, but information as to thepresence of chloroquine (CQ) resistance is scarce. In an observational study in Mangaluru, south-western India, of 116vivax malaria patients analyzed, 89.5% (102/114) had cleared parasitemia on days two or three of CQ treatment. Tworemaining patients presented on days four andfive without parasitemia. One hundred eight isolates of these 116 patientswere successfully sequenced forpvmdr1polymorphisms. Eight non-synonymous polymorphisms but no wild-typeisolate were detected. Tenpvmdr1haplotypes were observed with mutations T958M and F1076L occurring in all isolates,whereas the candidate CQ resistance marker Y976F was present in one isolate only.Pvmdr1polymorphisms were notassociated with early parasite clearance. The high proportion of early parasite clearance and the virtual absence ofpvmdr1Y976F and of sextuplepvmdr1mutants suggest that CQ in the study area is still sufficiently effective. However,the abundance ofpvmdr1mutations in the local parasite population warrants monitoring.

Item Type: Article
Uncontrolled Keywords: Plasmodium vivax pvmdr1
Subjects: Medicine > KMC Mangalore > Community Medicine
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 14 Nov 2019 11:27
Last Modified: 14 Nov 2019 11:27
URI: http://eprints.manipal.edu/id/eprint/154720

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