Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India

Gai, Prabhanjan P. and van Loon, Welmoed and Konrad, Siegert and Wedam, Jakob and Kulkarni, Suyamindra S. and Rasalkar, Rashmi and Boloor, Archith and Kumar, Arun and Jain, Animesh and *, Chakrapani M and Baliga, Shantaram B and Devi, Rajeshwari and Shenoy, Damodara and Gai, Pramod and P. Mockenhaupt, Frank (2019) Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India. Malaria Journal, 18 (1). pp. 1-8. ISSN 14752875

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AbstractBackground:Duffy blood group antigens serve as receptors for Plasmodium vivax invasion into erythrocytes, and they are determined by polymorphisms of the Duffy antigen receptor for chemokines (DARC), also known as Fy glycoprotein (FY ). Duffy negativity, i.e., absence of the antigens, protects against P. vivax infection and is rare among non-African populations. However, data on DARC polymorphisms and their impact on Plasmodium infection in India are scarce.Methods:In a case–control study among 909 malaria patients and 909 healthy community controls in Mangaluru, southwestern India, DARC polymorphisms T-33C (rs2814778), G125A (rs12075), C265T (rs34599082), and G298A (rs13962) were genotyped. Associations of the polymorphisms with the odds of malaria, parasite species and manifes-tation were assessed.Results:Among patients, vivax malaria (70%) predominated over falciparum malaria (9%) and mixed species infec-tions (21%). DARC T-33C was absent and C265T was rare (1%). FYB carriage (deduced from DARC G125A) was not associated with the risk of malaria per se but it protected against severe falciparum malaria (P=0.03), and hospitaliza-tion (P =0.006) due to falciparum malaria. Vice versa, carriage of DARC 298A was associated with increased odds of malaria (aOR, 1.46 (1.07–1.99), P=0.015) and vivax malaria (aOR, 1.60 (1.14–2.22), P=0.006) and with several reported symptoms and findings of the patients.Conclusion:This report from southern India is the first to show an independent effect of the DARC 298A polymor-phism on the risk of malaria. Functional studies are required to understand the underlying mechanism. Moreover, FYB carriage appears to protect against severe falciparum malaria in southern India.

Item Type: Article
Uncontrolled Keywords: Duffy, DARC , SNPs, Malaria, India, Plasmodium vivax, Plasmodium falciparum
Subjects: Medicine > KMC Mangalore > Community Medicine
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 14 Nov 2019 11:27
Last Modified: 14 Nov 2019 11:27
URI: http://eprints.manipal.edu/id/eprint/154722

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