The hox gene abdominal-B uses doublesexF as a cofactor to promote neuroblast apoptosis in the drosophila central nervous system

Ghosh, Neha and Bakshi, Asif (2019) The hox gene abdominal-B uses doublesexF as a cofactor to promote neuroblast apoptosis in the drosophila central nervous system. Development, 146 (16). pp. 1-16. ISSN 0950-1991

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Abstract

Highly conserved DM domain-containing transcription factors (Doublesex/MAB-3/DMRT1) are responsible for generating sexually dimorphic features. In the Drosophila central nervous system, a set of Doublesex (Dsx)-expressing neuroblasts undergo apoptosis in females whereas their male counterparts proliferate and give rise to serotonergic neurons crucial for adult mating behaviour. Our study demonstrates that the female specific isoform of Dsx collaborates with Hox gene Abdominal-B (Abd-B) to bring about this apoptosis. Biochemical results suggest that proteins AbdB and Dsx interact through their highly conserved homeodomain and DM domain, respectively. This interaction is translated into a cooperative binding of the two proteins on the apoptotic enhancer in the case of females but not in the case of males, resulting in female-specific activation of apoptotic genes. The capacity of AbdB to use the sex-specific isoform of Dsx as a cofactor underlines the possibility that these two classes of protein are capable of cooperating in selection and regulation of target genes in a tissue- and sex-specific manner. We propose that this interaction could be a common theme in generating sexual dimorphism in different tissues across different species.

Item Type: Article
Uncontrolled Keywords: Abdominal-B; doublesex; drosophila; neuroblast; apoptosis; sexual dimorphism.
Subjects: Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 19 Dec 2019 08:52
Last Modified: 19 Dec 2019 08:52
URI: http://eprints.manipal.edu/id/eprint/154773

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