Catalytic asymmetric oxidation of sulfides to sulfoxides using (R)-6,6�-Diphenyl-BINOL as a chiral ligand

Kini, Suvarna G and Shenoy, Gautham G (2019) Catalytic asymmetric oxidation of sulfides to sulfoxides using (R)-6,6�-Diphenyl-BINOL as a chiral ligand. Journal of Chemical Sciences, 131 (64). pp. 1-6. ISSN 0974-3626

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Abstract

The chiral metal complex produced in situ from (R)-6,6 -Diphenyl-BINOL and Ti(O−i−Pr)4 as a catalytic system for asymmetric sulfoxidation of aryl methyl and aryl benzyl sulfides in the presence of 70% aqueous TBHP as the oxidant has been investigated. The influence of variation of reagents mole ratios, temperature, solvent and oxidant was examined, and the optimized conditions were then used to oxidize a number of aryl methyl and aryl benzyl sulfides, producing sulfoxides in high enantiopurities (up to 90% ee) and good yields (up to 81%)

Item Type: Article
Uncontrolled Keywords: (R)-6,6-Diphenyl-BINOL; Enantiopure sulfoxides; Chiral ligand
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Library
Date Deposited: 24 Jan 2020 14:02
Last Modified: 24 Jan 2020 14:02
URI: http://eprints.manipal.edu/id/eprint/154786

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