Potentials of Diphenyl Ether Scaffold as a Therapeutic Agent: A Review

Kini, Suvarna G and Ekta, Rathi and Kumar, Avinash and Bhat, Varadaraj G (2019) Potentials of Diphenyl Ether Scaffold as a Therapeutic Agent: A Review. Mini-Reviews in Medicinal Chemistry, 19 (17). pp. 1392-1406. ISSN 1389-5575

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Abstract

Diphenyl ethers (DPE) and its analogs have exhibited excellent potential for therapeutic and industrial applications. Since the 19th century, intensive research is perpetuating on the synthetic routes and biological properties of DPEs. Few well- known DPEs are Nimesulide, Fenclofenac, Triclosan, Sorafenib, MK-4965, and MK-1439 which have shown the potential of this moiety as a lead scaffold for different pharmacological properties. In this review, we recapitulate the diverse synthetic route of DPE moiety inclusive of merits and demerits over the classical synthetic route and how this moiety sparked an interest in researchers to discern the SAR (Structure Activity Relationship) for the development of diversified biological properties of DPEs such as antimicrobial, antifungal, antiinflammatory & antiviral activities

Item Type: Article
Uncontrolled Keywords: Ullmann ether synthesis; Diphenyl oxide; Dowtherm; Enoyl-acyl carrier protein; Nimesulide; Triclosan
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Library
Date Deposited: 24 Jan 2020 14:00
Last Modified: 24 Jan 2020 14:00
URI: http://eprints.manipal.edu/id/eprint/154801

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