Evaluation of a mouthrinse containing guava leaf extract as part of comprehensive oral care regimen- a randomized placebocontrolled clinical trial

Nayak, Namratha and Varghese, Jothi M and Shetty, Seema and Bhat, Vinutha R and Durgekar, Tejal and Lobo, Richard and Nayak, Usha Y and Vishwanatha, U B (2019) Evaluation of a mouthrinse containing guava leaf extract as part of comprehensive oral care regimen- a randomized placebocontrolled clinical trial. BMC Complementary and Alternative Medicine, 19 (1). pp. 1-10. ISSN 1472-6882

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Background: The control of biofilm adherence on tooth surface has always been the keystone of periodontal therapeutic systems. However, prevalence of gingivitis suggest inadequacy of self-performed oral hygiene measures and need for adjunctive aid for mechanical plaque control. Oral rinses containing chlorhexidine, has been widely used however, with certain limitations. Herbal products have been used widely reflecting its action as alternative and complementary remedy. Hence, the purpose of the present study was to evaluate the antimicrobial and antioxidant efficacy of a Guava leaf extract based mouthrinse in patients with chronic generalized gingivitis as an adjunct to oral prophylaxis. Methods: Sixty subjects (n = 20) in compliance with the inclusion criteria were randomly assigned to one of the 3 study groups i.e. Group A- 0.15%Guava mouth rinse, Group B- 0.2% Chlorhexidine (CHX) mouth rinse, Group C- Distilled water (placebo). All the participants received professional oral prophylaxis and were dispensed with experimental mouth rinses and instructed to use for period of 30days. Clinical parameters such as gingival index, plaque index along with microbial colony forming units using plaque samples and antioxidant levels in saliva were estimated at baseline, 30 and 90 days’ time intervals. Results: All 3 groups showed gradual reduction in GI, PI and microbial counts. Considering the mean scores of recorded parameters at the scheduled time intervals, notable changes were observed between chlorhexidine and guava mouth rinse compared to placebo group. Although there was improvement in the antioxidant status in all study participants, yet there was no statistically significant difference observed. Conclusion: Guava mouth rinse can be used as an empirical adjunct to professional oral prophylaxis owing to its multifactorial properties and favourable acceptance. However, long term studies need to be conducted to validate its use for an extended period of time.

Item Type: Article
Uncontrolled Keywords: Chronic gingivitis, guava mouth rinse,chlorhexidine mouth rinse, microbial CFU counts, antioxidant levels
Subjects: Medicine > KMC Manipal > Biochemistry
Dentistry > MCODS Manipal > Periodontology
Medicine > KMC Manipal > Microbiology
Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Library
Date Deposited: 12 Feb 2020 04:36
Last Modified: 12 Feb 2020 04:36
URI: http://eprints.manipal.edu/id/eprint/154867

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