The utility of Urine-based sampling for cervical cancer screening in Low-resource settings

Sabeena, S and Ravishankar, N and Arunkumar, G (2019) The utility of Urine-based sampling for cervical cancer screening in Low-resource settings. Asian Pacific Journal of Cancer Prevention, 20 (8). pp. 2409-2413. ISSN 1513-7368

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Abstract

Background: WHO has recommended Visual Inspection with Acetic acid (VIA) or Human Papillomavirus (HPV) DNA testing if feasible, for cervical cancer screening in low income countries. However, the number of women undergoing screening is very low as a result of limited information, inadequate infrastructure and invasive nature of sampling. Methods: A cross sectional study was carried out comparing HPV DNA detection by Polymerase Chain Reaction (PCR) in paired cervical and urine samples procured from histologically confirmed cervical cancer cases. Results: Amongst the samples collected from 114 cervical cancer cases, HPV DNA was tested positive in cervical samples of 89 (78.1%) and urine samples of 55 (48.2%) patients. The agreement between the two sampling methods was 66.7% and the kappa value was 0.35 indicating a fair agreement. The sensitivity of HPV detection using urine samples was 59.6% (95% confidence interval 49.16%-69.15%) and the specificity was 92% (95% confidence interval 75.0%-97.8%). Conclusion: Even though not acceptable as an HPV DNA screening tool due to low sensitivity, the urine sampling method is inexpensive and more socially acceptable for large epidemiological surveys in developing countries to estimate the burden.

Item Type: Article
Uncontrolled Keywords: Cervical cancer; DNA- HPV; sampling; urine.
Subjects: Departments at MU > Manipal Centre for Virus Research
Departments at MU > Public Health
Depositing User: KMC Library
Date Deposited: 19 Feb 2020 05:47
Last Modified: 19 Feb 2020 05:47
URI: http://eprints.manipal.edu/id/eprint/154943

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