Ratio Analysis Evaluation of Dermal Collagen and Elastic Fiber Contents: A Comparison of the Horizontal and Vertical Directions of Skin Tissues

Kumar, Naveen and Kumar, Pramod and Nayak, Satheesha B and Aithal, Ashwini P and Guru, Anitha (2019) Ratio Analysis Evaluation of Dermal Collagen and Elastic Fiber Contents: A Comparison of the Horizontal and Vertical Directions of Skin Tissues. The Journal of Clinical and Aesthetic Dermatology, 12 (12). pp. 21-24.

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Abstract

Background: Stretching force on the skin leads to the widening of scars and/or hypertrophy. The uneven distribution pro� le of collagen and elastic � bers in the human dermis (evaluated based on their topographic areas) might determine the direction of incision for a more pleasing aesthetic result. Materials and methods: Full-thickness skin samples were collected in the horizontal and vertical directions from 15 areas of 32 human cadavers. The histological preparation of the skin samples was performed using special Verhoe� –van Gieson staining. Image analysis in the TissueQuant software was performed using photomicrographs. Quantitative fraction measures for collagen and elastic � bers were completed.From the data obtained, various ratios between collagen in the horizontal (CH) and vertical (CV) directions and elastic � bers in the horizontal (EH) and vertical (EV) directions were established and expressed as CH:CV and EH:EV. Results:In the areas where CV:CH was less than 1 (low ratio of signi� cance), the collagen content was signi� cantly higher in the horizontal direction than the vertical direction (CH>CV). However, this � nding is reversed (CV>CH) in areas where CV:CH is greater than 1 (high ratio of signi� cance).Similarly, in areas where EV:EH is less than 1 (low ratio of signi� cance), the elastic � ber content was signi� cantly higher in the horizontal direction than the vertical direction (EH>EV), whereas such is reversed (EV>EH) where EV:EH is greater than 1 (high ratio of signi� cance). Conclusion: The evaluation of ratios of dermal collagen and elastic � bers in di� erent directions together with the data of asymmetric distribution provide a useful guideline for aesthetic surgeons looking to place elective incisions in the direction that will ensure an improved aesthetically pleasing result

Item Type: Article
Uncontrolled Keywords: Collagen; Elastic; Ratio; Scar; Skin lines
Subjects: Medicine > MMMC Manipal > Anatomy
Depositing User: KMC Library
Date Deposited: 01 Jul 2020 06:42
Last Modified: 01 Jul 2020 06:42
URI: http://eprints.manipal.edu/id/eprint/154974

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