Salivary MMP-9 as a Biomarker for the Diagnosis of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Smriti, Komal and Chatterjee, Tilottama and Shenoy, Revathi Panduranga and Gadicherla, Srikanth and Pentapati, Kalyana Chakravarthy (2020) Salivary MMP-9 as a Biomarker for the Diagnosis of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma. Asian Pacific Journal of Cancer Prevention, 21 (1). pp. 233-238. ISSN 1513-7368

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Abstract

Objective: To compare the salivary MMP – 9 concentration among subjects with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMD), tobacco users, and control groups. Materials and methods:A total of 88 subjects were enrolled and divided into four study groups viz., OSCC (n=24), OPMD (n=20), tobacco habits (n=22), and healthy controls (n=22). All subjects gave unstimulated saliva samples for the evaluation MMP – 9 by ELISA kit. Demographic information like age, gender, type of tobacco, and duration of the habit were recorded.Results: Subjects with OSCC and OPMD had significantly higher mean MMP-9 levels than subjects with tobacco habits and control groups (P<0.001). Also, poorly differentiated OSCC group had significantly higher mean saliva MMP-9 than moderate and well-differentiated OSCC. The optimal cut-off point was 214.37 ng/mL with a sensitivity of 100% and specificity of 59% for OSCC versus the control group. The optimal cut-off point was as 205.87 ng/mL with a sensitivity of 100% and a specificity of 54% for OPMD versus the control group. Conclusion: The data obtained from this study indicated that OSCC and OPMD had an increased level of salivary MMP-9. Salivary MMP-9 could be a useful, non-invasive adjunct technique in the diagnosis, treatment, and follow-up of OSCC and OPMD

Item Type: Article
Uncontrolled Keywords: MMP; Saliva; Noninvasive; Biomarker; Cancer
Subjects: Medicine > KMC Manipal > Biochemistry
Dentistry > MCODS Manipal > Preventive and Community Dentistry
Dentistry > MCODS Manipal > Oral and Maxillofacial Surgery
Dentistry > MCODS Manipal > Oral Medicine and Radiology
Depositing User: KMC Library
Date Deposited: 01 Jul 2020 06:54
Last Modified: 01 Jul 2020 06:54
URI: http://eprints.manipal.edu/id/eprint/155036

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