Dathathri, Eshwari and lal, Satyapriya and Mittal, Mohit and Thakur, Goutam and Shounak, De (2019) Fabricating low-cost composite polymer-based micro needle patch for transdermal drug deliver. Applied Nanoscience. ISSN 2190-5509

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Abstract

Microneedle delivery patches are an emerging technology to attain painless and sustained delivery through the epidermis of the skin. This study is unique in its attempt to develop polymeric microneedles embedded with drug. Special polymer chitosan with hydrogel forming capability is cross-linked with PVA, a water-soluble polymer with excellent ilm strengthening ability and loaded with model drug diclofenac sodium. The microneedle patch was prepared by dipping an array of needles in a mold of chitosan-PVA composite (ratio 1:6), which upon drying was peeled of to result in the composite ilm. The ilm of chitosan-PVA in the ratio 1:6 when tested for mechanical behavior exhibited improved mechanical strength owing to use of PVA, the presence of efective cross-linking of PVA with chitosan was further veriied with FTIR. The release from drug-loaded needles was promising, as cross-linking with PVA enabled a sustained drug release of 20.17% at the end of 30 h. The release followed the Higuchi model with Fickian difusion, indicating a swelling-dependent release. The microneedle prepared using a composite of chitosan-PVA showed promising results indicating its potential to be used as a drug eluting transdermal patc

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