Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers

Fernandes, Amanda Velinna and Pydi, Chinna Raja and Verma, Ruchi and Kumar, Lalit (2020) Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers. Brazilian Journal of Pharmaceutical Sciences, 56. pp. 1-14. ISSN 1984-8250

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Abstract

Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively.In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections

Item Type: Article
Uncontrolled Keywords: Fluconazole; NLCs; Nanostructured lipid carriers; Fungal infections; Full factorial design; Design of experiment
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 02 Jul 2020 03:52
Last Modified: 02 Jul 2020 03:52
URI: http://eprints.manipal.edu/id/eprint/155186

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