Immunohistochemical and clinical significance of matrix metalloproteinase‑2 and its inhibitor in oral lichen planus

Agarwal, Neha and Carnelio, Sunitha and Rodrigues, Gabriel (2019) Immunohistochemical and clinical significance of matrix metalloproteinase‑2 and its inhibitor in oral lichen planus. Journal of Oral and Maxillofacial Pathology, 23 (3). pp. 1-6. ISSN 0973-029X

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Abstract

Background: Matrix metalloproteinases (MMP) are being considered important mediators in cancer invasion, and plenty of research is in progress. Our objective was to evaluate the presence of MMP‑2 and tissue inhibitor of metalloproteinase (TIMP‑2) in oral lichen planus (OLP) and to assess its role in the pathogenesis of OLP and as an indicator of malignant transformation. Materials and Methods: Immunohistochemical analysis for MMP‑2 and TIMP‑2 was performed in thirty histopathologically confirmed, formalin‑fixed, paraffin‑embedded specimens of OLP (24 cases of reticular and 6 cases of erosive LP). A semi‑quantitative analysis was done to assess the expression and distribution of this marker in these lesions. Results: In all cases of OLP, MMP‑2 expression was seen mainly in areas of lymphocytic inflammatory infiltrate (100%) in the lamina propria within the overlying epithelium. TIMP‑2 expression was seen more than 50% in the fibroblasts and basal and parabasal cells. Conclusion: The expression of MMP‑2 and TIMP‑2 was observed in all cases of OLP. However, a clinical 5‑year follow‑up of the lesion revealed no progression of the disease except for chronic exacerbation and regression of these lesions. Although our study considers MMP‑2 and TIMP‑2 as mediators in the pathogenesis of OLP, it still remains debatable whether they have a direct role to play in the disease process or whether they are suitable biomarkers to assess the disease progression.

Item Type: Article
Uncontrolled Keywords: Biomarkers; excision; inflammation; lichen planus; malignancy.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Medicine > KMC Manipal > Surgery
Depositing User: KMC Library
Date Deposited: 27 Jun 2020 08:32
Last Modified: 27 Jun 2020 08:32
URI: http://eprints.manipal.edu/id/eprint/155272

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