Comparison of serum levels of fructosamine and erythrocyte sodium potassium ATPase (Na+/K+ ATPase) in Gestational Diabetes Mellitus (GDM) and non-Gestational Diabetes Mellitus (non GDM) patients

Shenoy, Revathi P and Gagana, H and Varashree, BS and Priyanka, S (2019) Comparison of serum levels of fructosamine and erythrocyte sodium potassium ATPase (Na+/K+ ATPase) in Gestational Diabetes Mellitus (GDM) and non-Gestational Diabetes Mellitus (non GDM) patients. Reports of Biochemistry & Molecular Biology, 8 (3). pp. 260-266. ISSN 2322-3480

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Abstract

Background: The study aims at the comparison and correlation of serum levels of fructosamine and erythrocyte Na+/ K+ ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus (Non GDM). Methods: A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 20- 40 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects. Anonymized and left over fasting and 2 hours’ samples were collected from biochemistry laboratory, Kasturba Hospital, Manipal. Results: In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to be significant (p value<0.001) in both fasting and 2 hours (G2) blood glucose condition. Na+/ K+ ATPase did not show any significant variation between the groups. Correlation was not significant between the parameters. Conclusions: Fructosamine showed significant increase when compared between the groups, whereas significant correlation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomes inconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed in fructosamine and to find out the exact relationship between hyperglycaemia and Na+/ K+ ATPase activity.

Item Type: Article
Uncontrolled Keywords: Fructosamine; gestational diabetes mellitus; Na+/ K+ atpase enzyme activity; screening test.
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Library
Date Deposited: 27 Jun 2020 08:31
Last Modified: 27 Jun 2020 08:31
URI: http://eprints.manipal.edu/id/eprint/155277

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