Increased expression of P‑cadherin is an indicator of poor prognosis in breast cancer: a systematic review and meta‑analysis

Sridhar, Sriya and Rajesh, Christabelle and Jishnu, Padacherri Vethil and Jayaram, Pradyumna and Kabekkodu, Shama Prasada (2020) Increased expression of P‑cadherin is an indicator of poor prognosis in breast cancer: a systematic review and meta‑analysis. Breast Cancer Research and Treatment. pp. 1-13. ISSN 0167-6806

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Abstract

Purpose P-cadherin (CDH3), located at 16q22.1 belonging to classical cadherin family, is a calcium-dependent glycoprotein associated with cell to cell adhesion, migration, and invasion in cancer. This meta-analysis was conducted to examine the prognostic utility of P-cadherin expression in breast cancer (BC).Methods A comprehensive literature search was carried out using the available databases to obtain relevant research articles to test the relationship between P-cadherin and BC. Correlation of P-cadherin expression and disease-free survival (DFS) or overall survival (OS) was tested using hazard ratio (HR), relative risk (RR) at 95% confidence interval (CI) by univariate and/or multivariate analysis. A total of 11 studies from 7 countries were found to be relevant and were further subjected to statistical analysis to find an association between the P-cadherin expression with BC. Additionally, we have also performed a co-relation analysis of P-cadherin expression with GOBO and Cancertool in breast cancer using publicly available breast cancer datasets.Results Our study shows that P-cadherin expression is significantly linked with poor prognosis in the various subtypes of BC. The HR for OS and DFS was 1.87 (95% CI = 1.48–2.36) and 1.64 (95% CI = 1.18–2.27) respectively.Conclusions In this meta-analysis, we identified a positive correlation between the overexpression of P-cadherin and BC.Our study demonstrates that P-cadherin overexpression can be used as a prognostic indicator in BC

Item Type: Article
Uncontrolled Keywords: P-cadherin; Breast cancer; Prognosis; Overall survival; Disease-free survival; Meta-analysis
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 26 Jun 2020 08:59
Last Modified: 26 Jun 2020 08:59
URI: http://eprints.manipal.edu/id/eprint/155301

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