Salivary MMP-9 as a Biomarker for the Diagnosis of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Smriti, Komal and Chatterjee, Tilottama and Shenoy, Revathi-Panduranga and Gadicherla, Srikanth and Pentapati, Kalyana Chakravarthy (2020) Salivary MMP-9 as a Biomarker for the Diagnosis of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma. Asian Pacific Journal of Cancer Prevention, 21 (1). pp. 233-238. ISSN 1513-7368

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Abstract

Objective: To compare the salivary MMP – 9 concentration among subjects with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMD), tobacco users, and control groups. Materials and methods:A total of 88 subjects were enrolled and divided into four study groups viz., OSCC (n=24), OPMD (n=20), tobacco habits (n=22), and healthy controls (n=22). All subjects gave unstimulated saliva samples for the evaluation MMP – 9 by ELISA kit. Demographic information like age, gender, type of tobacco, and duration of the habit were recorded.Results: Subjects with OSCC and OPMD had significantly higher mean MMP-9 levels than subjects with tobacco habits and control groups (P<0.001). Also, poorly differentiated OSCC group had significantly higher mean saliva MMP-9 than moderate and well-differentiated OSCC. The optimal cut-off point was 214.37 ng/mL with a sensitivity of 100% and specificity of 59% for OSCC versus the control group. The optimal cut-off point was as 205.87 ng/mL with a sensitivity of 100% and a specificity of 54% for OPMD versus the control group. Conclusion: The data obtained from this study indicated that OSCC and OPMD had an increased level of salivary MMP-9. Salivary MMP-9 could be a useful, non- invasive adjunct technique in the diagnosis, treatment, and follow-up of OSCC and OPMD

Item Type: Article
Uncontrolled Keywords: MMP; Saliva; Noninvasive; Biomarker; Cancer
Subjects: Medicine > KMC Manipal > Biochemistry
Dentistry > MCODS Manipal > Preventive and Community Dentistry
Dentistry > MCODS Manipal > Oral and Maxillofacial Surgery
Dentistry > MCODS Manipal > Oral Medicine and Radiology
Depositing User: KMC Library
Date Deposited: 26 Jun 2020 08:05
Last Modified: 26 Jun 2020 08:05
URI: http://eprints.manipal.edu/id/eprint/155321

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