CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

Radhakrishnan, Raghu (2020) CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma. Medicina oral, patología oral y cirugía bucal, 25 (1). pp. 49-55. ISSN 1137-2834

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Abstract

Background: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langer� hans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Material and Methods: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epi�thelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. Results: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF�OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. Conclusion: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.

Item Type: Article
Uncontrolled Keywords: Premalignant lesions; oral submucous fibrosis; oral squamous cell carcinoma; immune response.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Library
Date Deposited: 25 Jun 2020 10:25
Last Modified: 25 Jun 2020 10:25
URI: http://eprints.manipal.edu/id/eprint/155325

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