Unravelling the insulin-like growth factor I-mediated photoprotection of the skin

Andrade, Melisa J and Satyamoorthy, K (2020) Unravelling the insulin-like growth factor I-mediated photoprotection of the skin. Cytokine and Growth Factor Reviews, 52. pp. 45-55. ISSN 1359-6101

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Chronic exposure of human skin to solar ultraviolet radiation (UVR) induces a range of biological reactions which may directly or indirectly lead to the development of skin cancer. In order to overcome these damaging effects of UVR and to reduce photodamage, the skin’s endogenous defence system functions in concert with the various exogenous photoprotectors. Growth factors, particularly insulin-like growth factor-I (IGF-I), produced within the body as a result of cellular interaction in response to UVR demonstrates photoprotective properties in human skin. This review summarises the impact of UVR-induced photolesions on human skin, discusses various endogenous as well as exogenous approaches of photoprotection described to date and explains how IGF-I mediates UVR photoprotective responses at the cellular and mitochondrial level. Further, we describe the current interventions using growth factors and propose how the knowledge of the IGF-I photoprotection signalling cascades may direct the development of improved UVR protection and remedial strategies.

Item Type: Article
Uncontrolled Keywords: Photobiology; keratinocytes; UVB radiation; insulin-like growth factors; photodamage; photoprotection.
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 04 Jul 2020 09:30
Last Modified: 04 Jul 2020 09:30
URI: http://eprints.manipal.edu/id/eprint/155413

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