Simulation of unit operations in formulation development of tablets using computational fluid dynamics

Hemamanjushree, S and Krishna, Vamshi T (2020) Simulation of unit operations in formulation development of tablets using computational fluid dynamics. American Association of Pharmaceutical Scientists, 21 (3). pp. 1-13. ISSN 1530-9932

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Tablets are the most customarily used solid oral unit dosage form for its better patient compliance. Preparation of these tablets include granulation, granule drying, die filling, and tablet coating as few unit operations and evaluation tests like dissolution test and disintegration test. These are the most crucial segments influencing the quality of the tablet. Critical analysis of the impact of factors like flow pattern, temperature, velocity, and other properties of fluid affecting the unit operations is obligatory to enhance their efficiency. Computational fluid dynamics (CFD), a combined mathematical and numerical approach, isused to analyze the process parameters of fluid affecting the abovementioned processes during tablet formulation. The equations governing the laws of conservation of energy, mass, and momentum are solved numerically utilizing CFD software for better understanding of the role of fluids within the tablet processing steps. This review not only focuses on discrete explanations on how CFD is utilized in formulation and evaluation of tablet but it is also a compilation of multiple research works performed on each unit operation by applying CFD.

Item Type: Article
Uncontrolled Keywords: Computational fluid dynamics; simulation tools; formulation development of tablets.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 04 Jul 2020 09:30
Last Modified: 04 Jul 2020 09:30

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