Dathathri, Eshwari and Thakur, Goutam and Koteshwara, KB and Kumar, Anil N V and Rodrigues, Fiona Concy (2020) Investigating the efect of freezing temperature and cross‑linking on modulating drug release from chitosan scafolds. Chemical Papers, 74 (6). pp. 1759-1768. ISSN 0366-6352

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Abstract

The aim of this study was to investigate the efect of altering design variables like cross-linking and freezing temperature (at a time) on morphology of freeze-dried chitosan scafolds and modulation of release of Diclofenac sodium (model drug).Freeze-dried chitosan scafolds produced at −80 °C, cross-linked with genipin, showed swelling of 163.52±9.95% with sustained drug release of 26.37±10.47% over 24 h (P<0.05). In comparison, uncross-linked scafolds produced at −80 °C showed higher swelling of 173.58±8.23% and drug release of 28.67±2.40% (P<0.05). Uncross-linked scafolds produced using freezing temperature of −20 °C also showed higher swelling of 228.77±9.84% and release of 30.58±3.25% (P<0.05).Release kinetics followed Higuchi model with Fickian difusion, thereby indicating a swelling-dependent release. Altering the design parameters also showed signifcant changes in pore size and porosity, thereby supporting the swelling and drug delivery behavior from scafolds

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