Favorable outcomes and reduced toxicity with a novel vinblastine-based non-high dose methotrexate (HDMTX) regimen (modified MCP-842) in pediatric anaplastic large cell lymphoma (ALCL): experience from India

Kalasekhar, VS (2020) Favorable outcomes and reduced toxicity with a novel vinblastine-based non-high dose methotrexate (HDMTX) regimen (modified MCP-842) in pediatric anaplastic large cell lymphoma (ALCL): experience from India. Leukemia & Lymphoma, 61 (4). pp. 912-918. ISSN 1029-2403

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Abstract

Anaplastic large cell lymphoma (ALCL) is a rare form of non-Hodgkin lymphoma (NHL) in children. Most treatment regimens include high-dose methotrexate (HDMTX), which is logistically difficult to administer in resource-limited settings. We evaluated the outcomes of pediatric ALCL patients treated on a uniform protocol (Modified Multicentric Protocol, MCP-842 regimen) at our hospital between January 2005 and December 2016. Of the 68 patients who received treatment on the Modified MCP842 protocol, 46 patients are alive in remission, 11(16%) had disease progression, 9(13%) relapsed after achieving remission, and 5(7%) had treatment-related mortality (TRM). Seventeen of 20 relapsed/progressed patients subsequently expired. With a median follow-up of 55 months (range 2–165 months), the 4-year event-free survival (EFS) and overall survival (OS) are 63% (95% CI of 50–73%) and 70%(95% CI of 57–79%), respectively. An indigenous protocol using vinblastine (without HDMTX and steroids) is feasible in a resource-limited setting and achieves outcomes comparable to regimens incorporating HDMTX, with lower toxicity

Item Type: Article
Uncontrolled Keywords: Pediatric ALCL; outcomes; vinblastine
Subjects: Medicine > KMC Manipal > Medical Oncology
Depositing User: KMC Library
Date Deposited: 03 Aug 2020 08:50
Last Modified: 03 Aug 2020 08:50
URI: http://eprints.manipal.edu/id/eprint/155476

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