Optimisation of carbon nanotubes for advanced diagnosis and biomedical application

Budihal, Dr. Suman Veerappa and Parwez, Khalid (2019) Optimisation of carbon nanotubes for advanced diagnosis and biomedical application. International Journal of Nanoparticles, 11 (3). pp. 217-238. ISSN 17532507

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Abstract

Abstract: Nanomaterials have a broad spectrum of applications in biomedical fields. The carbon nanotubes (CNTs) are among the most versatile and well-characterised members of this group of materials. This review aims to discuss how to utilise CNTs as a diagnostic tool. Functionalisation with antibodies has gained significance in recent years among the various way of functionalisation of CNTs. Antibodies make their surface sensitive to surroundings for immuno-sensing. Surface passivation with other proteins is required to inhibit the non-specific binding of biomolecules on the hydrophobic carbon nanotube surface for ultrasensitive detection of biological species. CNT-based immuno-sensors provide excellent results with a promising sensitivity and reproducibility and, in combination with novel devices [such as a microfluidic electrochemical biosensor, nanoelectromechanical systems (NEMS), paper-based analytical devices (PADs), field effect transistors (FET)]. This combination offers an attractive analytical approach for the fast, low-cost, and accessible detection of trace prognostic biomarkers, microbial pathogens, environmental pollutants, and toxins. Keywords: nanomaterials; carbon nanotubes; functionalisation; biosensor; immuno-sensor; field effect transistors; FETs; micro electro mechan

Item Type: Article
Uncontrolled Keywords: Keywords: nanomaterials; carbon nanotubes; functionalisation; biosensor; immuno-sensor; field effect transistors; FETs; micro electro mechanical systems; MEMS; paper-based analytical devices; PADs; tissue engineering
Subjects: Medicine > KMC Mangalore > Physiology
Depositing User: KMCMLR User
Date Deposited: 03 Nov 2020 09:08
Last Modified: 03 Nov 2020 09:08
URI: http://eprints.manipal.edu/id/eprint/155480

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