Comprehensive Review on Diabetes Associated Cardiovascular Complications - The Vitamin D Perspective

Rao, Yalla Durga and Manjrekar, Dr. Poornima and Adhikari, Dr. Prabha and *, Dr. Chakrapani M and *, Dr. Rukmini M S (2019) Comprehensive Review on Diabetes Associated Cardiovascular Complications - The Vitamin D Perspective. Cardiovascular and Hematological Disorders - Drug Targets, 19 (2). pp. 139-153. ISSN 1871529X

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Abstract

Abstract: Vitamin D, a steroid hormone is primarily known for its role in calcium and bone mineral homeostasis. Over the years, vitamin D has been implicated in various non-skeletal diseases. The extraskeletal phenomenon can be attributed to the presence of vitamin D receptors (VDRs) in almost all cells and identification of 1-α hydroxylase in extrarenal tissues. The vitamin D deficiency (VDD) pandemic was globally reported with increasing evidence and paralleled the prevalence of diabetes, obesity and cardiovascular diseases (CVDs). A dependent link was proposed between hypovitaminosis D glycemic status, insulin resistance and also the other major factors associated with type 2 diabetes leading to CVDs. Insulin resistance plays a central role in both type 2 diabetes and insulin resistance syndrome. These 2 disorders are associated with distinct etiologies including hypertension, atherogenic dyslipidemia, and significant vascular abnormalities that could lead to endothelial dysfunction. Evidence from randomised clinical trials and meta-analysis, however, yielded conflicting results. This review summarizes the role of vitamin D in the regulation of glucose homeostasis with an emphasis on insulin resistance, blood pressure, dyslipidaemia, endothelial dysfunction and related cardiov

Item Type: Article
Uncontrolled Keywords: Keywords: Vitamin D, diabetes, insulin resistance, dyslipidemia, hypertension, endothelial dysfunction, cardiovascular diseases.
Subjects: Medicine > KMC Mangalore > Biochemistry
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 03 Nov 2020 09:10
Last Modified: 03 Nov 2020 09:10
URI: http://eprints.manipal.edu/id/eprint/155511

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