Neuroprotective effects of resveratrol in Alzheimer’s disease

Rao, Mr. Y Lakshmisha and *, Dr. Ganaraja B and *, Dr. Teresa Joy and Pai, Dr. Mangala M and Ullal, Dr. Sheetal Dinkar and *, Dr. Murlimanju B V (2020) Neuroprotective effects of resveratrol in Alzheimer’s disease. [Frontiers in Bioscience, Elite, 12 (1). pp. 139-149. ISSN 19450494

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Abstract

1. ABSTRACT Alzheimer’s disease (AD) is a neurodegenerative disorder, which is commonly seen in older individuals. This is characterized by cognitive dysfunction, which leads to dementia. Pharmacological treatments for AD are mainly targeted on its symptoms like memory loss and cognitive impairment. The pathophysiology involved in AD is intra-neuronal accumulation of hyperphosphorylated tau protein as neurofibrillary tangle and extra cellular beta amyloid plaque deposition, which is due to oxidative stress. Here we review the neuro-protective effects of Resveratrol (RSV) and its treatment efficacy in AD. RSV is a naturally available polyphenolic compound, which has antioxidant, anticancerous, anti-inflammatory and anti-aging properties. RSV crosses blood brain barrier and exerts its antioxidant effect by enhancing the antioxidant enzymes. RSV is involved in Sirtuin (SIRT1) mediated lifespan extension activity. RSV has reduced glial activation and helped in increasing the hippocampal neurogenesis. RSV was able to decrease the expression of amyloid precursor protein, along with improvement of spatial working memory. Since RSV acts as an antioxidant, it can be safely used as oral drug.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease; Antioxidant effect; Dementia; Resveratrol, Review
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Physiology
Medicine > KMC Mangalore > Anatomy
Depositing User: KMCMLR User
Date Deposited: 03 Nov 2020 09:10
Last Modified: 03 Nov 2020 09:10
URI: http://eprints.manipal.edu/id/eprint/155520

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