Modified pectins for Colon specific drug delivery

Muvva, Aneesh and Chacko, Indhu Annie and Ghate, Vivek M and Lewis, Shaila Angela (2020) Modified pectins for Colon specific drug delivery. Indian Journal of Pharmaceutical Education and Research, 54 (2 Supl). s-12-s-18. ISSN 0019-5464

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Abstract

Treatment of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome and colonic cancer by targeting drug to the colon is a viable approach. Due to gastric degradation of drugs, proteins and peptides, only minimum amount of drug gets absorbed when administered orally and shows little therapeutic activity. Hence the strategy of delivering drugs to colon known as colon targeted drug delivery evolved. Pectin a naturally occurring biodegradable polysaccharide has gained importance as a carrier for colon-specific delivery attributed to swelling nature as well as the ability to resist gastric degradation. This review describes the chemistry of pectin, mechanism of action and various novel modified pectin formulations aimed at targeting the colon.

Item Type: Article
Uncontrolled Keywords: Colon targeting; Intestinal microflora; Modified pectin forms; Gelling property; biodegradable polysaccharide; Drug delivery.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 22 Sep 2020 04:31
Last Modified: 22 Sep 2020 04:31
URI: http://eprints.manipal.edu/id/eprint/155639

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