A Facile Solvent and Catalyst Free Synthesis of New Dihydro Pyrimidinones as Antimicrobial Agents

Hegde, Hemanth and Ahn, Chuljin and Gaonkar, Santosh L and Shetty, Nithin kumar (2019) A Facile Solvent and Catalyst Free Synthesis of New Dihydro Pyrimidinones as Antimicrobial Agents. Journal of the Korean Chemical Society, 63 (6). pp. 435-439. ISSN 1017-2548

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Abstract

An efficient one pot multicomponent synthesis of pyrimidinone derivatives of Biginelli type is described. 4- amino-6-aryl-pyrimidine-5-carbonitrile molecules were synthesized efficiently via three-component Biginelli-type condensation of aldehyde, malononitrile, and semicarbazone as urea substituent in the presence of a catalytic amount of PEG-400 as green medium under microwave irradiation. The reactions proceeded efficiently in the presence of microwave radiation to afford the desired products in good to excellent yields. Products have been confirmed by IR, and NMR spectral analysis. All the molecules were tested for their antimicrobial activity against E. coli, S. aureus, P. aeruginosa and C. tropicalis. Some of the compounds have shown moderate to good inhibition efficiency against both gram-positive and gram-negative bacteria. The potent activity was observed against the fungal species with minimum inhibition concentration 12.5 µg/mL.

Item Type: Article
Uncontrolled Keywords: Dihydropyrimidinones, One-pot synthesis, PEG-400, Microwave synthesis
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 25 Sep 2020 06:15
Last Modified: 25 Sep 2020 06:15
URI: http://eprints.manipal.edu/id/eprint/155648

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